基本信息
单刚，男，博士，网投领导者教授，药物化学专业博士生导师。2019年入选信誉最好的20个网投网站齐鲁青年学者项目和山东省泰山学者青年专家项目。
邮箱: gangshan@sdu.edu.cn
通讯地址：山东省济南市文化西路44号网投领导者
教育背景
2019.06–至今 网投领导者，药物化学专业，教授、博士生导师
2018.04–2019.04 哈佛大学医学院丹娜法伯癌症研究所，博士后
2015.09–2018.04 德国马普分子生理学研究所，博士后
2010.09–2015.07 清华大学网投领导者，博士
2006.09–2010.07 网投领导者，学士
研究方向
1.基于化学反应的诊断治疗药物开发：针对肿瘤微环境的特点，设计肿瘤特异 性的反应，开发近红外一区和二区的诊断治疗药物，用于肿瘤的治疗与活体成像。
2.新型生物兼容反应的开发及其在生物大分子标记和药物激活中的应用。
3.新型有机合成新方法的开发及其在药物研发中的应用。
承担项目
1.信誉最好的20个网投网站齐鲁青年学者项目
2.山东省泰山学者青年专家项目
3.国家自然科学基金青年基金项目
发表论文
1.G. Shan, J. Flegel, H. Li, C. Merten, S. Ziegler, A. P. Antonchick, H. Waldmann.* "C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Novel Hedgehog Pathway Inhibitors "Angew. Chem. Int. Ed.2018, 57, 14250-14254.
2. Z. Jia,G. Shan, C. G. Daniliuc, A. P. Antonchick, H. Waldmann.* "Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis"Angew. Chem. Int. Ed.2018,57, 14493-14497.
3.X.L. Yang+,G. Shan+, Z. Yang, G. Huang, C. Sheng, Y. Rao.* "One-pot Synthesis of Quaternary Carbon Centered Cyclobutanes via Pd(II)-catalyzed Cascade C(sp3)-H Activations"Chem. Comm.2017,53, 1534-1537.
4. X.L. Yang+,G. Shan+, L. Wang, Y. Rao.* "Recent advances in transition metal (Pd, Ni)-catalyzed C(sp3)H bond activation with bidentate directing groups"Tetrahedron Lett. 2016, 56, 819-836.
5.G. Shan, G. Huang, Y. Rao,*H. Zhang.*"Palladium-catalyzedortho-selective C-H bond chlorination of aromatic ketones"Chin. Chem. Lett.2015,26, 1236-1240.
6.G. Shan, G. Huang, Y. Rao.* "Palladium-Catalyzed Unactivated β-Methylene C(sp3)-HBond Alkenylation of Aliphatic Amides and Application in A Sequential C(sp3)-H/C(sp2)-HBond Alkenylation"Org. Biomol. Chem.2015,13, 697-701.
7. Y. Rao*,G. Shan, X. Yang. "Some Recent Advances in Transition-metal-catalyzedorthoSP2C–H Functionalization Using Ru, Rh, and Pd"Science China Chemistry,2014,57, 930-944.
8. X. Yang+,G. Shan+, Y. Rao.* "Synthesis of 2-Aminophenols and Heterocycles by RuCatalyzed Mono- and Double C-H Hydroxylation"Org. Lett.2013,15, 2334-2337.
9.G. Shan, X. Han, Y. Lin, S. Yu, Yu Rao.* "Broadening the Catalyst and Reaction Scopeof Regio- and Chemoselective C-H Oxygenation: A Convenient and Scalable Approach to2-Acylphenols by Intriguing Rh(II) and Ru(II) Catalysis "Org. Biomol. Chem.2013,11,2318-2322.
10.G. Shan+, X. Yang+, Y. Zong, Y. Rao.* "An Efficient Palladium Catalyzed C-HAlkoxylation of Unactivated Methylene and Methyl Groups with Cyclic Hypervalent Iodine(I3+) Oxidants"Angew. Chem. Int. Ed.2013,52, 13606-13610.
11. X. Sun+,G. Shan+, Y. Sun, Y. Rao.* "A General Approach for Regio- and ChemoselectiveC-H Chlorination/Bromination of Electron-Deficient Arenes via Weak Coordination and APreliminary Study of Priority Order of Relative Directing Group Ability"Angew. Chem. Int.Ed.2013,52, 4440-4444.
12.G. Shan, X. Yang, L. Ma, Y. Rao.* "Pd-Catalyzed C-H Oxygenation with TFA/TFAA:Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification"Angew. Chem. Int. Ed.2012,51, 13070-13074.
13.G. Shan, X. Sun, Q. Xia, Y. Rao.* "A Facile Synthesis of Substituted 2-AlkylquinolinesThrough [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at RoomTemperature"Org. Lett.2011,13, 5770-5773.
14.G. Shan, P. Liu, Y. Rao.* "A New Synthesis ofPyrazoles through LewisAcid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines"Org.Lett.2011,13, 1746-1749.
